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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFS
All Species:
12.73
Human Site:
S102
Identified Species:
23.33
UniProt:
P49914
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49914
NP_006432.1
203
23256
S102
I
E
S
P
E
E
I
S
L
L
P
K
T
S
W
Chimpanzee
Pan troglodytes
XP_001154891
203
23207
S102
I
E
S
P
E
E
I
S
L
L
P
K
T
S
W
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_852666
203
23320
S103
L
A
S
P
E
E
I
S
S
L
P
K
T
S
W
Cat
Felis silvestris
Mouse
Mus musculus
Q9D110
203
23183
A102
L
T
S
S
E
E
I
A
L
L
P
K
T
S
W
Rat
Rattus norvegicus
NP_001009349
203
23222
A102
L
T
A
P
E
E
V
A
L
L
P
K
T
S
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516124
97
11478
R22
K
K
Y
Q
E
A
Q
R
V
S
V
F
L
S
M
Chicken
Gallus gallus
XP_413857
210
23450
S111
L
S
S
A
E
D
I
S
S
L
T
L
T
S
W
Frog
Xenopus laevis
NP_001089249
205
23364
N101
L
S
S
V
D
E
I
N
Q
L
P
V
T
T
W
Zebra Danio
Brachydanio rerio
XP_002662791
199
22883
E100
L
K
D
M
E
D
M
E
T
L
P
L
T
A
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001097432
201
22863
E100
L
R
G
M
E
E
Y
E
S
L
P
L
T
K
W
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9XWE6
206
23542
D100
V
P
D
Q
T
A
F
D
N
L
P
S
T
L
W
Sea Urchin
Strong. purpuratus
XP_001183516
161
18411
G86
R
E
D
A
L
K
T
G
G
L
D
L
I
I
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40099
211
24040
Y117
D
L
K
P
Q
G
P
Y
Q
L
K
E
P
E
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
N.A.
86.2
N.A.
83.2
83.2
N.A.
35.4
66.6
55.6
60
N.A.
35.9
N.A.
37.8
42.3
Protein Similarity:
100
100
N.A.
94.5
N.A.
92.6
93
N.A.
43.3
80.9
80.4
80.3
N.A.
59.1
N.A.
55.8
59.1
P-Site Identity:
100
100
N.A.
80
N.A.
73.3
66.6
N.A.
13.3
53.3
46.6
33.3
N.A.
40
N.A.
26.6
13.3
P-Site Similarity:
100
100
N.A.
86.6
N.A.
86.6
93.3
N.A.
26.6
66.6
73.3
66.6
N.A.
46.6
N.A.
33.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
51.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
16
0
16
0
16
0
0
0
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
24
0
8
16
0
8
0
0
8
0
0
0
0
% D
% Glu:
0
24
0
0
70
54
0
16
0
0
0
8
0
8
0
% E
% Phe:
0
0
0
0
0
0
8
0
0
0
0
8
0
0
0
% F
% Gly:
0
0
8
0
0
8
0
8
8
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
16
0
0
0
0
0
47
0
0
0
0
0
8
8
8
% I
% Lys:
8
16
8
0
0
8
0
0
0
0
8
39
0
8
0
% K
% Leu:
54
8
0
0
8
0
0
0
31
93
0
31
8
8
0
% L
% Met:
0
0
0
16
0
0
8
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
0
0
0
0
8
8
0
0
0
0
0
0
% N
% Pro:
0
8
0
39
0
0
8
0
0
0
70
0
8
0
8
% P
% Gln:
0
0
0
16
8
0
8
0
16
0
0
0
0
0
0
% Q
% Arg:
8
8
0
0
0
0
0
8
0
0
0
0
0
0
0
% R
% Ser:
0
16
47
8
0
0
0
31
24
8
0
8
0
54
0
% S
% Thr:
0
16
0
0
8
0
8
0
8
0
8
0
77
8
0
% T
% Val:
8
0
0
8
0
0
8
0
8
0
8
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
77
% W
% Tyr:
0
0
8
0
0
0
8
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _